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Anti-Aging Restorative Cream

Skinceutical's Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the patented lipid ra ... Read full description




Anti-Aging Restorative Cream

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Skin Type: Dry, Normal, Oily, Combination, Sensitive

Skin Concern: Dehydrated, Aging

A patented vand unique anti-aging cream to nourish dry skin & refill cellular lipids. U.S. Patent No. 10,137,073.

Skinceutical's Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish dry skin and reverse signs of aging. Optimal for anti-aging skincare, this bespoke lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair. As one of our best anti aging creams, 2:4:2 potently nourishes aging skin which leads to improvements in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores the essential skin lipids: natural cholesterol, ceramides, and fatty acids.
  • Improves the appearance of skin texture, fullness, and pore appearance.
  • Improves the look of skin evenness and overall radiance.
  • Unique and specific lipid stabilization system in a lightweight and fast-absorbing texture.
  • Reduces the adjustment period to retinoids by up to 1 week while combating dryness. (see Science & Proof)
  • Paraben-, and dye-free.
  • Ideal for normal, aging, and dry skin types


In an 8-week study, Triple Lipid Restore 2:4:2 drastically improved the appearance of key visible signs of accelerated aging.

  • 66% improvement in smoothness
  • 35% improvement in laxity
  • 20% improvement in evenness
  • 26% improvement in radiance
  • 44% improvement in pore appearance

In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.

First, apply a small amount between fingertips. Warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest areas. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

Aging skin is constantly and increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of fatty acids, natural cholesterol, and ceramides. This lipid loss occurs with age and compromises skin’s natural protective barrier. This results in visible signs of accelerated aging as the skin loses its ability to effectively self-repair. From this, visible signs of aging may appear more pronounced, in the form of dullness, uncomfortable tightness, skin roughness and loss of facial fullness.

Triple Lipid Restore 2:4:2 is our first & best anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio. This unique and specific formulation contains a maximized concentration of pure lipids easily utilized by skin.

Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids by up to 1 week while reducing dryness.

  • 2% Pure Ceramides 1 & 3
    Included in a larger family of ceramides, and proven to synergistically increase the optimal barrier function and hydration
  • 4% Natural Cholesterol
    Proven to accelerate barrier recovery in aging skin to improve the appearance of skin fullness and overall radiance
  • 2% Fatty Acids
    Aids in structural integrity of skin lipids to optimize your skin’s overall lipid balance and improve skin elasticity
  • Essential oil blend
    Combination of rosemary, lavender and peppermint oil for a cooling and nourishing feeling
Full ingredient list
Skinceuticals US - Physician Insight


Je pense que Triple Lipid Restore 2:4:2 est la meilleure crème correctrice sur le marché. Je la recommande à tous mes patients après une intervention chirurgicale pour permettre de lutter contre la sécheresse naturelle qui se produit après l’opération. Ils l’adorent!

Dr. Sapra

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