It is recommended to apply hyaluronic acid for skin topically during your morning routine, as well as your nighttime skincare routine. Hyaluronic acid can be incoporated in your skincare at any age, but it is beneficial to start using the ingredient as early as possible to prevent signs of aging and dry skin. You'll notice your skin will look more hydrated and plump after only a few uses, but to see a more drastic change in your skin such as diminishing fine lines and wrinkles, it can take up to a few months.