A.G.E. Interrupter Advanced
This next-generation anti-aging cream is formulated with 18% concentrated Proxylane (+20% more activ ... Read full description
Skin Type: Dry, Normal, Combination, Sensitive
Skin Concern: Aging, Dullness/Uneven Texture
Features
A.G.E. Interrupter Advanced is a potent corrective cream treatment that helps reverse visible signs of aging impacted by collagen decline and glycation, including wrinkles, laxity, and dullness.This next-generation anti-aging cream is formulated with 18% concentrated Proxylane (+20% more active than previous A.G.E. Interrupter), 4.25% Wild Fruit Flavonoid blend (+12.5% more active), and new ingredients such as 0.1% Glycyrrhetinic Acid. This advanced technology is clinically shown to reduce the look of five types of wrinkles (forehead wrinkles, glabellar line, crow’s feet, nasolabial folds, and marionette lines), restore the skin's firmness & elasticity, and enhance skin's radiance.
*Due to the formula’s high levels of flavonoids, this cream's color may vary but will remain effective.
Benefits
- Helps reduce the look of signs of aging impacted by collagen decline
- Reduces the appearance of global fine lines by -14.1% and targeted deep wrinkles by -7.9%
- Skin feels firmer
- Skin appears more radiant for a healthier-looking complexion
- Delivers rich hydration, with a luxurious, satin finish
- Free of parabens, drying alcohol, and dyes


CLINICAL STUDY
In a 12-week study, A.G.E. Interrupter Advanced reduced global fine lines by -14.1% and targeted deep wrinkles by -7.9%.
A.G.E. Interrupter Advanced clinically improved attributes associated with skin aging and glycation, including lines and deep wrinkles in multiple facial zones:
- +30% skin density
- -14% global fine lines
- -11.5% forehead wrinkles
- -11.2% nasolabial folds
- -7.9% marionette wrinkles
- -7.3% glabellar wrinkles
- -7% crow’s feet
After 12 weeks:
- 95.9% immediately agree product applies easily
- 93.2% immediately agree product absorbs quickly
- 94.7% agree product is suitable for daily use
Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced wrinkle cream onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.
This multi-phase process occurs when excess sugar binds to proteins in skin. Oxidative stressors, like UV, pollution, and diet, expedite the reaction, transforming the bound proteins into A.G.E.s—advanced glycation end-products. A.G.E.s turn flexible proteins brittle, making newly glycated collagen lose its critical regenerative ability. As these degenerated proteins cannot break down to be replaced, skin is ultimately weakened, accelerating signs of visible aging including wrinkles.
A.G.E. Interrupter Advanced is a potent corrective anti-aging cream designed to help reverse visible aging impacted by collagen decline and glycation on the face. This potent anti-aging cream treatment features a high-concentration combination of Proxylane, wild fruit flavonoids, glycyrrhetinic acid, HEPES, and niacinamide to improve visible signs of aging such as wrinkles, laxity, and dullness.
Helps support the skin’s integrity and correct visible signs of aging, like wrinkles and laxity.
• 4.25% WILD FRUIT FLAVONOIDS
Combination of blueberry and pomegranate extracts helps reduce oxidative stress, which can be linked to A.G.E. formation, and protect against free radical damage.
• 0.1% GLYCYRRHETINIC ACID
Helps counter dull tone, which can be linked to A.G.E. accumulation, and is known for its soothing properties.
• 3% HEPES
Activates natural enzymes in the skin to promote even cell turnover while hydrating the skin.
• 1% NIACINAMIDE
Water-soluble vitamin, also known as vitamin B3, soothes and helps support the skin’s moisture barrier.
Full ingredient list
PHYSICIAN INSIGHT

"Clients are getting a heavy hitter with A.G.E. Interrupter Advanced as it is a corrective moisturizer that contains ingredients that improve the signs of aging. I love this product as it does double duty and a little goes a long way!"
Dr. Lori Shapiro MD, Thornhill Dermatology Centre, Dermatologist
FREQUENTLY ASKED QUESTIONS
Answers to Your Frequently Asked A.G.E. Interrupter Advanced Questions
CLINICALLY PROVEN RESULTS

In a 12-week study, A.G.E. Interrupter Advanced reduced global fine lines by -14.1% and targeted deep wrinkles by -7.9%.
A.G.E. Interrupter Advanced improved attributes associated with skin aging and glycation, including lines and deep wrinkles in multiple facial zones:
+30% | Skin density | |
---|---|---|
-14% | Global fine lines | |
-11.5% | Forehead wrinkles | |
-11.2% | Nasolabial folds | |
-7.3% | Glabellar wrinkles | |
-7% | Crow's feet |
HOW DOES GLYCATION AGE YOUR SKIN?
An accumulation of the body's natural sugars can damage skin during a reaction called glycation. In this process, sugars bind to the proteins responsible for keeping skin supple, soft and youthful-looking, like collagen and elastin. This forms harmful molecules known as Advanced Glycation End-Products (A.G.E.), which cause protein damage and lead to visible wrinkles, loss of firmness and aging skin.

GLYCATION DOs AND DON'Ts
Help reverse visible aging impacted by collagen decline and glycation
DO
- Protect skin with an antioxidant serum
- Use A.G.E. Interrupter Advanced
- Wear sunscreen
DON'T
- Forget sun protection
- Smoke
- Consume excess sugar and alcohol
